Journal article
Genomic and Phenotypic Comparisons Reveal Distinct Variants of Wolbachia Strain wAlbB
J Martinez, PA Ross, X Gu, TH Ant, SM Murdochy, L Tong, A da Silva Filipe, AA Hoffmann, SP Sinkins
Applied and Environmental Microbiology | AMER SOC MICROBIOLOGY | Published : 2022
DOI: 10.1128/aem.01412-22
Abstract
The intracellular bacterium Wolbachia inhibits virus replication and is being harnessed around the world to fight mosquito-borne diseases through releases of mosquitoes carrying the symbiont. Wolbachia strains vary in their ability to invade mosquito populations and suppress viruses in part due to differences in their density within the insect and associated fitness costs. Using whole-genome sequencing, we demonstrate the existence of two variants in wAlbB, a Wolbachia strain being released in natural populations of Aedes aegypti mosquitoes. The two variants display striking differences in genome architecture and gene content. Differences in the presence/absence of 52 genes between variants ..
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Grants
Awarded by Wellcome Trust
Funding Acknowledgements
The study was supported by the Wellcome Trust (202888, 108508) to S.P.S. and by the National Health and Medical Research Council (1132412, 1118640 [https://www.nhmrc.gov.au]) to A.A.H. L.T. and A.d.S.F. were funded by the MRC (MC_UU_12018/12). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. This research was funded in part by the Wellcome Trust [Grant number 202888, 108508]. For the purpose of open access, the author has applied a CC BY public copyright licence to any Author Accepted Manuscript version arising fromthis submission. Qiong Yang assisted in Wolbachia density assays.